Tuesday, January 22, 2008

What is DHODA?

I just named my blog "Dhoda" without much thought and there was very little reason behind the name. However I became curious recently and 'google'd the word and here's some interesting insight

Dhoda - Dhoda is a popular sweet in Haryana and Punjab. It is something totally different than doodh barfi as it contains wheat.

Dhoda - It can be a last name (surname) of a person in some parts of India.

Dhoda - This is a place situated in Jhelum, Punjab, Pakistan.

Biggest surprise of them all is this last one:

Dihydroorotate dehydrogenases (DHODs) catalyze the oxidation of (S)-dihydroorotate to orotate, the fourth step and only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. A description is given of the crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A (DHODA) complexed with the product of the enzyme reaction orotate. The structure of the complex to 2.0 A resolution has been compared with the structure of the native enzyme. The active site of DHODA is known to contain a water filled cavity buried beneath a highly conserved and flexible loop. In the complex the orotate displaces the water molecules from the active site and stacks above the DHODA flavin isoalloxazine ring, causing only small movements of the surrounding protein residues. The orotate is completely buried beneath the protein surface, and the orotate binding causes a significant reduction in the mobility of the active site loop.

Now, seriously my reaction is "Dhoda!"

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